翻訳と辞書 Words near each other ・ 2-alkenal reductase ・ 2-alkyn-1-ol dehydrogenase ・ 2-Amino-1,2-dihydronaphthalene ・ 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine ・ 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase ・ 2-Amino-3-carboxymuconic semialdehyde ・ 2-Amino-4-deoxychorismate dehydrogenase ・ 2-Amino-4-deoxychorismate synthase ・ 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase ・ 2-Amino-4-hydroxy-6-pyrophosphoryl-methylpteridine ・ 2-Amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one ・ 2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase ・ 2-Aminoacridine ・ 2-aminoadipate transaminase ・ 2-aminobenzenesulfonate 2,3-dioxygenase ・ 2-Aminoethoxydiphenyl borate ・ 2-aminoethylphosphonate—pyruvate transaminase ・ 2-aminohexano-6-lactam racemase ・ 2-aminohexanoate transaminase ・ 2-Aminoindane ・ 2-Aminoisobutyric acid ・ 2-aminomuconate deaminase ・ 2-Aminomuconic acid ・ 2-Aminomuconic semialdehyde ・ 2-Aminophenol ・ 2-Aminopurine ・ 2-Aminopyridine ・ 2-Aminotetralin ・ 2-Arachidonoylglycerol ・ 2-Arachidonyl glyceryl ether Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク 2-Aminoethoxydiphenyl borate ： ウィキペディア英語版 2-Aminoethoxydiphenyl borate |Section2= |Section3= }} 2-Aminoethoxydiphenyl borate (2-APB) is a chemical that acts to inhibit both IP3 receptors〔Diver JM, Sage SO, Rosado JA (2001). The inositol trisphosphate receptor antagonist 2-aminoethoxydiphenylborate (2-APB) blocks Ca2+ entry channels in human platelets: cautions for its use in studying Ca2+ influx. ''Cell Calcium, 30''(5), 323-329.〕 and TRP channels (although it activates TRPV1, TRPV2, & TRPV3 at higher concentrations).〔Xu SZ, Zeng F, Boulay G, Grimm C, Harteneck C, Beech DJ (2005). Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effect. ''British Journal of Pharmacology, 145''(4), 320-328.〕〔Bootman, MD, Collins, TJ, Makenzie, L, Roderick, HL, Berridge, MJ, & Peppiatt, CM (2002). 2-Aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated Ca2+ entry but an inconsistent inhibitor of InsP3-induced Ca2+ release. ''The FASEB Journal, 16''(10), 1145-1150.〕 In research it is used to manipulate intracellular release of calcium ions (Ca2+) and modify TRP channel activity, although there its lack of specific effects make it less than ideal under some circumstances. Additionally, there is evidence that 2-APB acts directly to inhibit gap junctions made of connexin26 or connexin32.〔Tao, L, & Harris, AL (2007). 2-aminoethoxydiphenyl borate directly inhibits channels composed of connexin26 and/or connexin32. ''Molecular Pharmacology, 71''(2), 570-579.〕 Increasing evidence showed that 2-APB is a powerful modifier of store-operated calcium channels (SOC) function, low concentration of 2-APB can enhance SOC while high concentration induces a transient increase followed by complete inhibition.〔Ma HT, et al. (2000) Requirement of the inositol trisphosphate receptor for activation of store-operated Ca2+ channels. Science 287:1647–1651.〕〔Prakriya M, Lewis RS (2001) Potentiation and inhibition of Ca2+ release-activated Ca2+ channels by 2-aminoethyldiphenyl borate (2-APB) occurs independently of IP 3 receptors. J Physiol 536:3–19.〕〔Ma HT, Venkatachalam K, Parys JB, Gill DL (2002) Modification of store-operated channel coupling and inositol trisphosphate receptor function by 2-aminoethoxydiphenyl borate in DT40 lymphocytes. J Biol Chem 277:6915–6922.〕 == References == 〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「2-Aminoethoxydiphenyl borate」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.